Tuck played college football for the University of Notre Dame, and was chosen by the Giants in the third round of the 2005 NFL Draft. 

In front of a record-setting American television audience, Tuck had a spectacular game in Super Bowl XLII by repeatedly pressuring New England Patriots quarterback Tom Brady and recording two sacks and a forced fumble. The Giants went on to win Super Bowl XLVI as well and it was Tuck's 2nd Super Bowl ring in 5 years. 

He signed with the Oakland Raiders in 2014.