Oher played college football at the University of Mississippi, and earned unanimous All-American honors. His life through his final year of high school and first year of college is one of the subjects of Michael Lewis's 2006 book, The Blind Side: Evolution of a Game, and was featured in the Academy Award-winning 2009 film The Blind Side. The Baltimore Ravens selected him in the first round of the 2009 NFL Draft.
Oher was the starting right tackle for the Ravens during their Super Bowl XLVII win on February 3, 2013.