A 15-year NBA veteran, Kerr won four consecutive NBA Championship rings (three with the Chicago Bulls from 1996-1998 and one with the San Antonio Spurs in 1999). Kerr was the second player in NBA history to win championships with two different teams in consecutive seasons.

Drafted by the Phoenix Suns in the 1988 NBA Draft, Kerr was traded to the Bulls in 1989. He spent three years there and played one season with the Orlando Magic before being traded to the Chicago Bulls in 1993 and was part of the Bulls' team that set a record for the most wins in a season (72) during the 1995-96 season.

Kerr made the memorable shot that gave the Chicago Bulls the win over the Utah Jazz in Game 6 of the 1997 NBA Finals, making them back-to-back NBA World Champions. He was a member of the Bulls' team when they repeated their victory over the Jazz in the 1998 NBA Finals, he was then traded to the San Antonio Spurs where he helped them earn an NBA title the following year.

He retired from the Spurs following the 2003 season. At the time of his retirement, he held the NBA record for the highest single-season three-point shooting percentage (.524 in 1994-95). Twice led the NBA in three-point percentage in 1990 with .507 and 1995 with .524. He also retired as the all-time leader in three-point shooting percentage for a career (.454). He has spent most of his post NBA playing career as a GM in the NBA and as a college and NBA analyst.