In the 2005 NBA Draft, Andrew Bynum was selected 10th overall by the Los Angeles Lakers. At age 17 years, 244 days, Bynum was 12 days younger than former Indiana Pacers player Jermaine O'Neal, the previous youngest player drafted by an NBA team.

After selecting him in the draft, the Lakers hired Hall of Famer Kareem Abdul-Jabbar to work with Bynum. He helped the Lakers win NBA Championships in 2099 and 2010.

On April 11, 2012, Bynum grabbed a career and an NBA season-high 30 rebounds against the San Antonio Spurs to become only the fifth Lakers player ever to register at least 30 rebounds in a single game. Bynum finished the regular season with career highs in minutes per game (tied NBA 24th overall), rebounds per game (NBA 3rd overall), and points per game (NBA 20th overall). He also finished with the 3rd highest field-goal percentage in the league and 6th overall in blocks per game. He was traded to the Phiadelphia 76ers in 2012. He was later traded to the Cleveland Cavaliers, then to the Chicago Bulls in 2014.