In 1979 Zoeller became one of only three golfers to have won The Masters in his first appearance in the event. His other win in a major championship came at the 1984 U.S. Open.

Zoeller joined the Champions Tour in 2002 and won a senior major, the Senior PGA Championship that year. He also won the 2004 MasterCard Championship.

His PGA Tour wins include: 1979 Andy Williams-San Diego Open Invitational, The Masters, 1981 Colonial National Invitation, 1983 Sea Pines Heritage, Panasonic Las Vegas Pro Celebrity Classic
1984 U.S. Open, 1985 Hertz Bay Hill Classic, 1986 AT&T Pebble Beach National Pro-Am, Sea Pines Heritage, Anheuser-Busch Golf Classic.