Nicknamed "Huggy Bear", Huggins previously held the head coaching positions at the University of Cincinnati (1989–2005) and Kansas State University (2006–2007). As of 2012, he ranks eighth in winning percentage and fourth in victories among active Division I coaches. He is one of only a few active Division I coaches with 700 or more career victories. Huggins has been to 15 total NCAA tournaments, including 14 of the last 15 seasons. Huggins' teams have participated in the postseason 25 times, including two Final Fours: 1992 with Cincinnati, 2010 with West Virginia. 

On April 5, 2007, he accepted an offer to return to coach his alma mater of West Virginia University. After leading the Mountaineers to a Sweet 16 appearance, Huggins signed an 11-year contract with the university after the season ended.